TY  - JOUR
TI  - Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
AU  - M Kuro-o
AU  - Y Matsumura
AU  - H Aizawa
AU  - H Kawaguchi
AU  - T Suga
AU  - T Utsugi
AU  - Y Ohyama
AU  - M Kurabayashi
AU  - T Kaname
AU  - E Kume
AU  - H Iwasaki
AU  - A Iida
AU  - T Shiraki-Iida
AU  - S Nishikawa
AU  - R Nagai
AU  - Y I Nabeshima
PY  - 1997
JO  - PubMed
DO  - 10.1038/36285
UR  - https://doi.org/10.1038/36285
AB  - A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes. A defect in klotho gene expression in the mouse results in a syndrome that resembles human ageing, including a short lifespan, infertility, arteriosclerosis, skin atrophy, osteoporosis and emphysema. The gene encodes a membrane protein that shares sequence similarity with the beta-glucosidase enzymes. The klotho gene product may function as part of a signalling pathway that regulates ageing in vivo and morbidity in age-related diseases.
ER  -