Research institution
Medizinische Hochschule Hannover
DE
2 researchers0 verified2 linked papers7,622 indexed citations
Researchers
Public research profiles associated with Medizinische Hochschule Hannover.
Research from this institution
Publications linked through researcher authorship records.
2014 · Science · 7,063 citations
The new frontier of genome engineering with CRISPR-Cas9
The advent of facile genome engineering using the bacterial RNA-guided CRISPR-Cas9 system in animals and plants is transforming biology. We review the history of CRISPR (clustered regularly interspaced palindromic repeat) biology from its initial discovery through the elucidation of the CRISPR-Cas9 enzyme mechanism, which has set the stage for remarkable developments using this technology to modify, regulate, or mark genomic loci in a wide variety of cells and organisms from all three domains of life. These results highlight a new era in which genomic manipulation is no longer a bottleneck to experiments, paving the way toward fundamental discoveries in biology, with applications in all branches of biotechnology, as well as strategies for human therapeutics.
2019 · Journal of Hepatology · 559 citations
Update of the statements on biology and clinical impact of occult hepatitis B virus infection
In October 2018 a large number of international experts with complementary expertise came together in Taormina to participate in a workshop on occult hepatitis B virus infection (OBI). The objectives of the workshop were to review the existing knowledge on OBI, to identify issues that require further investigation, to highlight both existing controversies and newly emerging perspectives, and ultimately to update the statements previously agreed in 2008. This paper represents the output from the workshop.